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Cagrilintide monotherapy produces a meaningful weight-loss effect (−12% at 68 weeks in REDEFINE-1) and is appropriate for amylin-· Obesity and weight management · Type 2 diabetes and glycemic control · Appetite and energy intake regulation · Non‑alcoholic fatty liver disease (NAFLD) · Cardiovascular risk factors (e.g., blood lipids, blood pressure)receptor mechanistic research